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    Promethazine is an antihistamine medicine that relieves the symptoms of allergies. It's more likely to make you feel sleepy than other antihistamines. It's used for: You can buy promethazine from pharmacies, where it's often sold as Avomine, Phenergan or Sominex. You can also buy promethazine mixed with other medicines, such as paracetamol, dextromethorphan, pholcodine or pseudoephedrine, to treat coughs and colds or pain. Popular brand names include Day & Night Nurse and Night Nurse. It comes as tablets, capsules and a liquid that you swallow. If you or your child have been prescribed promethazine, follow your doctor's instructions about how and when to take it. Only take promethazine when you need it - for example, if you're unable to sleep because you're worrying about something or your cold symptoms are keeping you awake. Promethazine comes in 10mg, 20mg and 25mg tablets and a liquid that you swallow. Phenergan tablets and elixir contain the active ingredient promethazine hydrochloride, which is a type of medicine called a sedating antihistamine. Histamine is a substance produced by the body as part of its defence mechanisms. These can include inflammation in the nose or airways, rashes, and itching of the skin, eyes, nose or throat. Promethazine blocks histamine from binding to its receptors in various parts of the body and this stops it causing the symptoms of an allergic reaction. Promethazine also blocks histamine receptors in an area of the brain called the vomiting centre, which is responsible for causing feelings of sickness and for the vomiting reflex. It is activated when it receives nerve messages from the vestibular apparatus in the middle ear. The vestibular apparatus provides constant feedback to the brain about our body position. When something disturbs the vestibular apparatus, such as movements of the head when travelling by boat or car, nerve signals are sent from the vestibular apparatus to the vomiting centre. This can cause the symptoms of motion sickness, such as nausea, dizziness or spinning sensations (vertigo) and vomiting.

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