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    -kə, and Tadacip for the treatment of pulmonary arterial hypertension. It initially was developed by the biotechnology company ICOS, and then again developed and marketed worldwide by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Food and Drug Administration (FDA) approved Cialis for treating the signs and symptoms of benign prostatic hyperplasia (BPH) as well as a combination of BPH and erectile dysfunction when the conditions coincide. Cialis tablets, in 2.5 mg, 5 mg, 10 mg, and 20 mg doses, are yellow, film-coated, and almond-shaped. The approved dose for pulmonary arterial hypertension is 40 mg (two 20 mg tablets) once per day (OD). On November 21, 2003 the FDA approved tadalafil (as Cialis) for sale in the United States as the third ED prescription drug pill (after sildenafil citrate (Viagra) and vardenafil (Levitra)). Like sildenafil and vardenafil, tadalafil is recommended as an 'as needed' medication. Tadalafil was approved in May 2009 in the United States for the treatment of pulmonary arterial hypertension and is under regulatory review in other regions for this condition. In late November 2008, Eli Lilly sold the exclusive rights to commercialize tadalafil for pulmonary arterial hypertension in the United States to United Therapeutics for an upfront payment of $150 million. Under the definition of “erectile dysfunction” is considered to be an erection insufficient for successful sexual intercourse. In accordance with the statistics every two men out of ten face this problem. At the same time if the man could not manage to perform a high-quality and successful sexual intercourse, it does not mean that he has to run to the doctor the very next day. Indeed, sometimes, overstrain, nervousness, dissatisfaction with a partner may cause a bad erection. It has to be understood that erectile dysfunction does not appear instantly. Therefore, if for a long time a man has been observing erectile problems, then it is worthwhile to focus on this and start taking some measures. Erectile dysfunction results from both psychological and physical factors. Psychological factors include: overwork, abstinence from sexual acts with women, excessive drinking, and constant stress at work.

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