Regurgitation is different than vomiting although the two can mimic each other. Regurgitation occurs when food comes back up without any abdominal effort as it does with vomiting. The most common condition to cause persistent regurgitation and weight loss is called megaesophagus. This occurs when the esophagus (the tube that takes food from the mouth to the stomach) either fails to develop (congenital form) or becomes flaccid and cannot move food into the stomach. The latter form can occur due to toxins and many other diseases and conditions. Certain dog breeds seem to have a higher occurrence of this condition, particularly large and giant breed dogs. A higher incidence is seen in the German Shepherd, Great Dane, Irish setter, Labrador retriever, Irish Wolfhound, and Newfoundland dog breeds. europe meds online buy kamagra Commonly reported side effects of sildenafil include: dyspepsia, headache, visual disturbance, and flushing. 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Stick with ads for the online stores you know & trust. Pulmonary hypertension (PH/ PAH) is a term used to describe unusually high blood pressure in the blood vessel transporting blood from the right side of your dog’s heart to its lungs. (ref) All blood returning from your dog’s body makes that journey to replenish its oxygen content. Ordinary hypertension (high blood pressure) describes the situation in which your dog’s blood pressure is abnormally high in the arteries and capillaries throughout its body - not just its pulmonary artery and the right side of its heart. When a dog (or a cat for that matter) develops pulmonary hypertension, the right side of its heart is working harder than it should. We evaluated the efficacy of oral sildenafil citrate in dogs with congenital idiopathic megaoesophagus (CIM). Twenty-one puppies were randomly assigned to two groups (treatment and control). The dogs were given sildenafil oral suspension 1 mg/kg every 12 hours for 14 days or placebo in a masked fashion. Clinical signs (frequency of regurgitation and weight gain) and oesophagrams (relative oesophageal diameter, ROD) were evaluated in order to assess the efficacy of drug treatment, by examiners who were unaware of the study protocol. In addition, a set of in vitro experiments on isolated samples of canine lower oesophageal sphincter (LOS) was performed, and the effects of increasing concentrations of sildenafil on basal tone and electrically-stimulated motility were assessed. Sildenafil administration significantly reduced the number of regurgitation episodes (0.88±1.40 v 2.65±1.56, P If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s Rights Link service. You will be able to get a quick price and instant permission to reuse the content in many different ways. 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