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Metformin overdose death

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    Metformin overdose death


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    Metformin is a drug commonly prescribed to treat diabetes. Overdosing involving the drug metformin is rare when used alone (without additional diabetic medications) at recommended dosing. Symptoms of metformin overdose result from a condition called lactic acidosis. Lactic acidosis can occur at normal dosages, but is seen predominantly in overdose. Symptoms include abdominal pain, vomiting, diarrhea, tachycardia, agitation, confusion, lethargy, coma, and death. Hypoglycemia (low blood sugar) is seldom seen in patients using metformin. Taking glucose tablets will not treat metformin overdose. In the setting of breathlessness at rest or on minimal exertion from conditions such as advanced cancer or end-stage cardiorespiratory diseases, regular, low-dose sustained-release morphine significantly reduces breathlessness safely, with its benefits maintained over time. Like loperamide and other opioids, morphine acts on the myenteric plexus in the intestinal tract, reducing gut motility, causing constipation. The gastrointestinal effects of morphine are mediated primarily by μ-opioid receptors in the bowel. By inhibiting gastric emptying and reducing propulsive peristalsis of the intestine, morphine decreases the rate of intestinal transit. Reduction in gut secretion and increased intestinal fluid absorption also contribute to the constipating effect. Opioids also may act on the gut indirectly through tonic gut spasms after inhibition of nitric oxide generation. Clinical studies consistently conclude that morphine, like other opioids, often causes hypogonadism and hormone imbalances in chronic users of both sexes.

    Metformin overdose death

    Metformin and Fatal Lactic Acidosis - Medsafe Home Page, Management of Sulfonylurea Overdose California Poison.

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  7. Symptoms of metformin overdose result from a condition called lactic acidosis. Lactic acidosis can occur at normal dosages, but is seen predominantly in overdose. Symptoms include abdominal pain, vomiting, diarrhea, tachycardia, agitation, confusion, lethargy, coma, and death.

    • How do I Treat a Metformin Overdose? - Health FAQ
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    • Metformin Overdosage - News-Medical. Net

    Metformin is a biguanide used in the treatment of type 2 diabetes mellitus. It lowers hepatic glucose production and peripheral insulin. ciproxina Poljoprivredna TV emisija „U našem ataru“ je namenjena poljoprivrednicima kojima je brza i tačna informacija od izuzetnog značaja za njihovu proizvodnju. Dell'Aglio DM, Perino LJ, Kazzi Z, et al. Acute metformin overdose examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors a systematic review of the literature.

     
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