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    Oral: -Initial dose: 0.1 mg orally 2 times a day (morning and bedtime) -Titration: Increments of 0.1 mg orally per day may be made at weekly intervals to desired response -Maintenance dose: 0.2 to 0.6 mg orally per day in divided doses -Maximum dose: 2.4 mg orally per day in divided doses Comments: -Taking the larger portion of the oral daily dose at bedtime may minimize transient adjustment effects of dry mouth and drowsiness Transdermal patches: -Initial dose: 0.1 mg/24 hr patch applied every 7 days -Maintenance dose: If, after 1 to 2 weeks the desired reduction in blood pressure is not achieved, increase the dosage by adding another 0.1 mg/24 hr patch or changing to a larger system -Maximum dose: Doses above two 0.3 mg/24 hr patches applied every 7 days is usually not associated with additional efficacy Comments: -The transdermal patch should be applied to a hairless area of intact skin on the upper outer arm or chest. -Each new patch should be applied on a different skin site from the previous location. -If the patch loosens during 7-day wearing, the adhesive cover should be applied directly over the system to ensure good adhesion. -There have been rare reports of the need for patch changes prior to 7 days to maintain blood pressure control. -When substituting patches for the oral formulation or for other antihypertensive drugs, physicians should be aware that the antihypertensive effect of the patches may not commence until 2 to 3 days after initial application; therefore, gradual reduction of prior drug dosage is advised. Some or all previous antihypertensive treatment may have to be continued, particularly in patients with more severe forms of hypertension. Use: For hypertension, alone or in combination with other antihypertensive agents Epidural infusion: -Initial dose: 30 mcg/hr as a continuous infusion -Titration: May be titrated up or down depending on pain relief and occurrence of adverse events Maximum dose 40 mcg/hr as a continuous infusion Use: For the treatment of severe pain (in combination with opiates) in cancer patients that is not adequately relieved by opioid analgesics alone. Drug Combo May Help Treat Kids With ADHD - WebMD is it illegal to order viagra online Is Clonidine Safe for Children? - MedicineNet Clonidine for Children Uses, Instructions & Side Effects
     
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