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    Citalopram is fifth in effectiveness (after mirtazapine, escitalopram, venlafaxine, and sertraline) and fourth in cost-effectiveness. The ranking results were based on the meta-analysis by Andrea Cipriani. In another analysis by Cipriani, citalopram was found to be more efficacious than paroxetine and reboxetine, and more acceptable than tricyclics, reboxetine, and venlafaxine, but less efficacious than escitalopram. A meta-analysis, including studies with fluoxetine, paroxetine, sertraline, escitalopram, and citalopram versus placebo, showed SSRIs to be effective in reducing symptoms of premenstrual syndrome, whether taken continuously or just in the luteal phase. A 2009 multisite randomized controlled study found no benefit and some adverse effects in autistic children from citalopram, raising doubts whether SSRIs are effective for treating repetitive behavior in children with autism. This side effect, if present, should subside as the body adjusts to the medication. Citalopram is considered safe and well tolerated in the therapeutic dose range. Distinct from some other agents in its class, it exhibits linear pharmacokinetics and minimal drug interaction potential, making it a better choice for the elderly or comorbid patients. order neurontin overnight Citalopram (Lu 10-171), a new bicyclic phthalane derivative, is an extremely potent inhibitor of neuronal serotonin (5-HT) uptake but has no effect on the uptake of noradrenaline(NA) and dopamine (DA) and no antagonistic activity towards 5-HT, histamine, gamma aminobutyric acid (GABA), acetylcholine, and morphine receptors. It is an extremely specific and potent inhibitor of neuronal 5-HT uptake. Uptake mechanisms for other transmitter amines are not influenced by the drug. The SSRI citalopram has a greater effect on proliferation and a lesser effect on apoptotic activity. It affects cell cycle regulation by increasing proliferative potential and decreasing apoptotic activity in a site specific manner that may be indicative of hyperplasia. Citalopram alters FGF, MSX and TGFB expression in osteoblast cell culture Citalopram is devoid of cardiotoxic effects even when animals are exposed to concentrations far above the therapeutic level. In man citalopram is metabolized to compounds which are also potent 5-HT-uptake inhibitors without effect on noradrenaline(NA) uptake and which are found in lower concentrations than citalopram itself.

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    Citalopram is an antidepressant in the selective serotonin reuptake inhibitor (SSRI) class. Prescribed under the brand name Celexa, citalopram is used to treat depression and sometimes prescribed for alcoholism, panic disorder, premenstrual dysphoric disorder, social phobia, or eating disorders. Although there are some people who struggle with prescription drug abuse and abuse citalopram, abuse is rare because these medications do not cause euphoria like other drugs of abuse. However, even people who take citalopram as prescribed may experience short- and long-term side effects. Call now to speak to a consultant about your treatment options Call Now (888) 340-8966 100% CONFIDENTIAL Short-term side effects of citalopram can include: Citalopram can also cause a condition called serotonin syndrome, particularly if it is combined with tricyclic antidepressants, fentanyl, lithium, tramadol, trytophan, buspirone, amphetamines, or St. This condition requires emergency medical attention, so call 911 if symptoms arise. Symptoms include: Long-term use of antidepressants may put people at risk for type 2 diabetes, and SSRIs may cause heart rhythm abnormalities at higher doses. A European study linked citalopram with increased electrical abnormalities of the heart and that these abnormalities became worse with increasing doses. Those with pre-existing heart conditions should speak with their doctor before taking citalopram, even as prescribed. Some people who take SSRIs may problems with blood clotting because of decreased serotonin in blood platelets. This leaflet contains answers to some common questions about Cipramil. It does not contain all the information that is known about Cipramil. It belongs to a group of medicines called selective serotonin reuptake inhibitors (SSRIs). It does not take the place of talking to your doctor or pharmacist. Your doctor has weighed the risk of you using this medicine against the benefits he/she expects it will have for you. They are thought to work by their actions on brain chemicals called amines which are involved in controlling mood. If you have any concerns about using this medicine, ask your doctor or pharmacist. Depression is longer lasting or more severe than the "low moods"everyone has from time to time due to the stress of everyday life. It is thought to be caused by a chemical imbalance in parts of the brain. This imbalance affects your whole body and can cause emotional and physicalsymptoms such as feeling low in spirit, loss of interest in activities, being unable to enjoy life, poor appetite or overeating, disturbed sleep, often waking up early, loss of sex drive, lack of energy and feeling guilty over nothing. Cipramil corrects this chemical imbalance and may help relieve the symptoms of depression.

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