Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Alternative for plaquenil Best malaria medication for chloroquine resistant malaria Plaquenil con alcohol Plaquenil’s long half-life in the body can cause irreversible and progressive damage, Dr. Fung said. Similarly, one study reported that 16 women who’d taken hydroxychloroquine or chloroquine, or a combination of the agents, showed no improvement seven years after stopping drug therapy, and progression occurred in six of the cases. 2 PLAQUENIL is used concomitantly with other arrhythmogenic drugs. Mefloquine and other drugs known to lower the convulsive threshold PLAQUENIL can lower the convulsive threshold. Co-administration of PLAQUENIL with other antimalarials known to lower the convulsion threshold e.g. mefloquine may increase the risk of convulsions. The Plaquenil is used to treat the Sjogren's, not directly treat the neuropathy. If she feels the neuropathy is caused by the Sjogren's, then I guess she feels treating the underlining cause will help the SFN. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Can plaquenil cause neuropathy Reasonably Well Plaquenil and Hypoglycemia, PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION Uses for hydroxychloroquineChloroquine pillsZydus hydroxychloroquine glutenAximum dose of plaquenil Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Plaquenil causes and treats neuropathy? - NeuroTalk Support.. Common and Rare Side Effects for Plaquenil Oral. Mutations in the SCN9A or SCN10A gene can cause small fiber neuropathy. These genes provide instructions for making pieces the alpha subunits of sodium channels. The SCN9A gene instructs the production of the alpha subunit for the NaV1.7 sodium channel and the SCN10A gene instructs the production of the alpha subunit for the NaV1.8 sodium channel. Another thing I should say. The Plaquenil is used to treat the Sjogren's, not directly treat the neuropathy. If she feels the neuropathy is caused by the Sjogren's, then I guess she feels treating the underlining cause will help the SFN. It's actually not very effective in this manner. View detailed reports from patients taking plaquenil who experienced neuropathy peripheral. Reports are from official medical reports as well as online extractions from user reviews and forum discussions.