Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Lysosomotropic agent chloroquine which Lc3b chloroquine Malaria drug hydroxychloroquine Prednisone and hydroxychloroquine Today, Plaquenil and other antimalarials are also used to treat and help prevent symptoms caused by certain autoimmune diseases such as rheumatoid arthritis RA, systemic lupus erythematosus, and discoid lupus, even though these diseases are not caused by malaria parasites. Jan 5, 2011 -- People with early rheumatoid arthritis RA who smoke are less likely to respond to treatment with two of the most commonly used medications -- an older disease modifying antirheumatic drug called methotrexate and biologic drugs known as TNF blockers, according to a new study in January’s Arthritis & Rheumatism. Oct 11, 2008 Lupus and smoking. Well, allright, I hope this doesn't turn into a topic where I set myself up for multiple lectuers. Let me start off by saying that yes, I do know that smoking can trigger flares and can cause plaquenil not work as well as it can not to mention all the usual emphsema, asthma, and lung cancer issues. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil and smoking Relationship between blood hydroxychloroquine and., Smoking May Interfere With RA Treatment - WebMD Alternative to plaquenil for raHydroxychloroquine otc Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil Uses, Dosage & Side Effects -. Lupus and smoking -. Drug spotlight on hydroxychloroquine Lupus Foundation of.. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia. Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Can nicotine have effects on plaquenil? i have rheumatoid arthritis and i smoke. i am on plaquenil the antimalria drug that treats my arthritis, and i was wondering if the nicotine could effect my plaquenil. Answer Save. 5 Answers.