It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. How long do you have to take hydroxychloroquine side effects Hydroxychloroquine reactive arthritis Hydroxy chloroquine rheumatoid arthritis side effects Dec 16, 2008 I have to say that the best I feel is on Plaquenil and doxycycline, with steroids occasionally. I have a flare. I wish that I could find one Dr that would treat me the same as a doctor in Gainesville Florida treated me. so that I could continue to feel better. Plaquenil alone does at first give you night terrors and insomnia. User Reviews for Plaquenil to treat Lyme Disease, Arthritis. The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. I was just prescribed plaquenil to treat the cyst form of lyme. The usage of the drug says it is to suppress the immune system in the treatment of lupus. Why would you want to do this if you have lyme. I thought steriods and drugs that suppress the immune system make treatment much slower. I am reluctant to take it. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil for lyme treatment Plaquenil hydroxychloroquine sulfate dosing, indications., User Reviews for Plaquenil to treat Lyme Disease, Arthritis - When is the best time to take plaquenilNonbiological dmard antimalarial hydroxychloroquine plaquenilHydroxychloroquine sulfate 200 mg tab side effectsWhat is chloroquine phosphateHow long will plaquenil stay in your system Mar 02, 2011 Hydroxychloroquine is also widely used in the treatment of post-Lyme arthritis that can be induced by Lyme disease. The action of the drug may involve both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis.2” How does Plaquenil Work ? - Road Back Foundation. Plaquenil questions -. My current treatment protocol for chronic Lyme and.. Please help me as I'm supposed to start a new regimen of meds for lyme. Currently on biaxin, omnicef and about to add plaquenil. I've read good things about it but also bad side effects. Can anyone please help me with this. I don't want to take anything that has really bad side effects. Many different drugs can be used as DMARDs in the treatment of RA, but some are used more often than others. DMARD Side Effects and Use Hydroxychloroquine Plaquenil and sulfasalazine. For example doxycycline seem to be working better when ph was higher. Following, adjustment of ph level can cause effective treatment of plaquenil with lyme disease. The problem with plaquenil is that it can cause irritation of the bowel.