Additionally, another exception occurred while executing the custom error page for the first exception. Download PDF Drug-induced ocular side effects are back in the spotlight, thanks to the Academy’s revision of its recommendations on screening for retinal toxicity from chloroquine and its analogue hydroxychloroquine (Plaquenil). Plaquenil liver kidney toxicity Water hydroxychloroquine Is plaquenil a diuretic This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. With Plaquenil Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. Dry skin Loss of appetite Abdominal bloating Upset stomach Stomach cramps Retinal damage There is a small chance that retinal damage will occur while taking hydroxychloroquine Plaquenil or chloroquine Aralen. “Rick” Fraunfelder, MD, director of the Registry and associate professor of ophthalmology at Oregon Health & Science University in Portland. There are hundreds of drugs with potential retinal toxicity—so many that the National Registry of Drug-Induced Ocular Side Effects doesn’t stratify them by incidence or effect, said Frederick W. Retinal deposits plaquenil Rx Side Effects New Plaquenil Guidelines and More - American., Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy Plaquenil and ibuprophenMalaria hypnozoites resistant to chloroquinePlaquenil maculopathy visual field So I went to the ophthalmologist which was my third opinion and have been continuing to see him for the past 3 1/2 years. I am going blind because of the retinal atrophy due to the plaquenil Normally after you stop plaquenil your eyes will stay at the damage level that was caused to it, but in rare cases the damage will continue. Has anyone experienced plaquenil toxicity with damage to eyes?. Plaquenil and spots on skin DailyStrength. Retinal Screening for Hydroxychloroquine Plaquenil Toxicity.. The Retina Reference. Home; Retinal Diseases; Basal Laminar Drusen; About; Contact; Retinal Anatomy; Retinal Diseases; Home; Basal Laminar Drusen. Basal laminar drusen is a condition in which yellow round deposits of lipid waste accumulate between the base of the retinal pigment epithelium and Bruch's membrane in the outer retina. Irreversible retinal damage observed in some patients who had received hydroxychloroquine sulfate; significant risk factors for retinal damage include daily doses of hydroxychloroquine sulfate greater than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. It is now considered for new disease applications in diabetes, heart disease and adjunct cancer therapies 2.