Chemical structure of chloroquine

Discussion in 'Online Pharmacies Of Canada' started by carbonix, 17-Mar-2020.

  1. JJ Okocha Moderator

    Chemical structure of chloroquine


    Information also provided for 3,600 nuclides and 4,400 nuclide decay modes. Editor's note: Some chemicals in this database contain more information than others due to the original reason this information was collected and how the compilation was accomplished.

    Methotrexate and plaquenil for psoriatic arthritis Plaquenil laser hair removal Chloroquin functional groups

    The novel finding of the present study is that chloroquine is a zinc ionophore, which contributes to our understanding of chloroquine's biological activity in human cancer cells. While chloroquine has been studied in biomedical research 12, 13 and used for the treatment of malaria 1 and other human diseases 25, 26, this activity of the compound has not been previously reported. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Occasionally it is used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. Structure, properties, spectra, suppliers and links for Chloroquine diphosphate, 50-63-5, Chloroquine Phosphate.

    To resolve this problem, over the years, I compiled chemical names and identifiers into a personal database, cross referencing regulatory and health safety information when possible. While working with material safety data sheets (MSDS), I found that manufacturers sometimes used obscure names for constituent chemicals and I didn't always have a good idea of what I was dealing with.

    Chemical structure of chloroquine

    Chloroquine sulfate C18H28ClN3O4S - PubChem, Chloroquine - Wikipedia

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  7. Chloroquine is related in structure to quinine but more potent against Plasmodium falciparum, ovale, malariae and vivax, and better tolerated than quinine. Chloroquine remains the first choice of antimalarial prophylaxis as well as treatment. Chloroquine is available in tablets of 250 and 500 mg in generic forms and under the brand name Aralen.

    • Chloroquine - LiverTox - NCBI Bookshelf.
    • Chloroquine diphosphate C18H32ClN3O8P2 ChemSpider.
    • Chemical Structure Search - ChemSpider.

    Chloroquine CQ is a lysosomotropic agent with an extensive range of biological effects 1. Historically known for its anti-malarial activity, chloroquine is a widely used biological research tool for studying autophagy inhibition. Research studies demonstrate that chloroquine accumulates in acidic lysosomes and increases the lysosomal pH. The aminoalkyl side chain in chloroquine helps in the accumulation of the drug inside the food vacuole and assists in the complexation of the quinoline nucleus with the porphyrin system. Modification of this side chain either by varying its length or attaching new chemical groups can circumvent chloroquine resistance. Unless otherwise noted, the contents of the FDA website gov, both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA.

     
  8. web0987 Well-Known Member

    The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine. P-Chloroquine Tablet 250 mg Peoples Pharma Ltd. Chloroquine diphosphate salt - Sigma-Aldrich Emzor Chloroquine Syrup - EMDEX
     
  9. TohaToha Well-Known Member

    Dr Meducci vet's blog Toxicology Methemoglobinemia The potassium cyanide test can distinguish between methemoglobin and sulfhemoglobin. After the addition of a few drops of potassium cyanide, methemoglobin turns bright red, but sulfhemoglobin remains dark brown. This is due to the binding of methemoglobin to cyanide, forming cyanomethemoglobin, which is bright red in color.

    What is MethemoglobinemiaCausesSymptomsTreatment.