Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Does plaquenil have generic Plaquenil eye chart Plaquenil for celiac Does plaquenil suppress the immune system Annular atrophic lichen planus with lesional thinning, hyperpigmentation, and residual scarring after 2 months of combined treatment with hydroxychloroquine 400 mg and acitretin 25 mg both once daily. Purpose Hydroxychloroquine HCQ is a systemic antimalarial used to treat cutaneous and systemic lupus erythematosus and other connective tissue diseases. Mucocutaneous hyperpigmentation is a well-documented side effect of HCQ that occurs in 10-25% of users. Figure 4. Annular atrophic lichen planus with lesional thinning, hyperpigmentation, and residual scarring after 2 months of combined treatment with hydroxychloroquine 400 mg and acitretin 25 mg both once daily. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil hyperpigmentation treatment Common and Rare Side Effects for Plaquenil Oral, Treatment of hydroxychloroquine-induced hyperpigmentation of. Pill plaquenil generic dog bone shappedMefloquine or plaquenil Hydroxychloroquine HCQ was initially indicated for the treatment of malaria, but more recently its anti-inflammatory and immune modulating properties have been utilized for treatment of multiple dermatologic and rheumatologic diseases. Persistent cutaneous hyperpigmentation due to.. Annular Atrophic Lichen Planus Responds to Hydroxychloroquine.. Systemic Scleroderma Skin Involvement Hyperpigmentation and.. Skin hyperpigmentation is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Omniscan, and have Arteriogram Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Drug-induced skin pigmentation accounts for 10–20% of all cases of acquired hyperpigmentation. Pigmentation may be induced by a wide variety of drugs; the main ones implicated include non-steroidal anti- inflammatory drugs NSAIDs, phenytoin, antimalarials, amiodarone, antipsychotic drugs, cytotoxic drugs, tetracyclines, and heavy metals.