The doctor said that given where I am right now (constant low level pain and light swelling of my hands and wrists but no joint damage showing up on xrays or the ultrasound), she gave me a choice of starting on either Plaquenil or Methotrexate. She went over some info on each drug and then gave me some time to think about which would be better for me. My largest concerns center around the side effects of each... Can plaquenil cause numbness in tailbone area and legs Hydroxychloroquine anti inflammatory action Flomax and plaquenil Was the plaquenil controlling your RA symptoms? The trouble is you lose hair on Methotrexate too. But after losing heaps when I first went on it, I have stabalised now, I have thinner hair but it still looks fine and healthy. If plaq was working for your symptoms I'd go back on it. If you feel like the RA is escallating then go for mtx. Overall, the triple therapy regimen was found to be similar in efficacy to etanercept Enbrel and methotrexate, with no significant differences between treatment groups in outcomes, including radiographic progression, pain, quality of life, or major side effects or adverse events. 3. Methotrexate in combination with biologic DMARDs I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. With Plaquenil, the possibility of permanent vision damage scares me. Difference between hydroxychloroquine and methotrexate Is Injectable Methotrexate or Oral Methotrexate Better?, Combinations of conventional & biologic DMARDs Plaquenil and etohPlaquenil and being in the sunChloroquine autophagy miceEye doctor hydroxychloroquine Methotrexate vs plaquenil side effects long term and short term The only problem is the Plaquenil causes severe headaches that interfer with my daily activities also. But the Dr suggested I try Methotrexate instead. Methotrexate vs plaquenil side effects long term and short.. Does anyone take methotrexate and hydroxychloroquine.. Hydroxychloroquine and nausea Hi it's me again. - NRAS. The distinction between using methotrexate to treat cancer and to treat rheumatoid arthritis is important. Technically speaking, methotrexate is a “cancer drug” — and it’s used to treat different kinds of cancer, including breast cancer. That’s because methotrexate attacks fast-dividing cells, which include cancer cells. Between groups per-protocol analysis after intervention Mean SD LPPAI in methotrexate group at baseline, 4.63 1.83, was significantly higher than that in hydroxychloroquine group, 3.46 0.94, P = 0.04. reveals LPPAI difference between the two groups at Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects.