Chloroquine phosphate synthesis

Discussion in 'Hydroxychloroquine Plaquenil' started by revolutions, 13-Mar-2020.

  1. JOHNOZZY XenForo Moderator

    Chloroquine phosphate synthesis


    Visit Stack Exchange My intuition tells me that the nitrogen in the ring is more nucleophilic than the exocyclic amine. All this is not very promising and any attempt to optimize this reaction is fighting problems you would not have if you had decided for a more reasonable and well-established alternative in the first! A quick-and-dirty electrostatic potential calculation using B88LYP/6-31G(d) on the PM3 geometry shows a large electron density (blue and violet) on the ring nitrogen and lower density (yellow) on the exocyclic amine: Are there conditions that might work? That would be the synthesis of chloroquine from 4,7-dichloroquinoline and 4-diethylamino-1-methylbutylamine, where both starting materials are available through well-known procedures.

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    Mar 22, 2018 [email protected] This feature is not available right now. Please try again later. Chloroquine might be getting new life as an antiviral treatment for the novel coronavirus that emerged in Wuhan, China in late 2019 and has infected some 25,000 people in more than 25 countries. For decades, the drug was a front-line treatment and prophylactic for malaria. Each tablet contains 500 mg of Chloroquine phosphate USP, equivalent to 300 mg Chloroquine base. Inactive Ingredients colloidal silicon dioxide, dibasic calcium phosphate, hydroxypropylmethylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate80, pregelatinized starch.

    It's a pretty untypical approach to chloroquine and you didn't tell how you would synthesize 7-chloro-3-aminoquinoline and the secondary chloride. There is a good chance that the planned reaction will furnish a quarternary ammonium salt as a side product: The reaction will not necessary stop at this point.

    Chloroquine phosphate synthesis

    Synthesis of chloroquine from 4-amino-7-chloroquinoline, Could an old malaria drug help fight the new coronavirus?

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  6. How to use Chloroquine Phosphate. Take this medication by mouth, usually with food to prevent stomach upset, exactly as directed by your doctor. Daily or weekly dosing, dosage amount, and length.

    • Chloroquine Phosphate - WebMD.
    • Chloroquine - FDA prescribing information, side effects..
    • Chloroquine diphosphate ≥99%HPLC Selleck ATM/ATR..

    Sigma-Aldrich offers a number of Chloroquine phosphate products. View information & documentation regarding Chloroquine phosphate, including CAS, MSDS & more. Chloroquine phosphate is freely soluble in water—practically insoluble in alcohol, in chloroform and in ether. Two polymorphic forms of chloroquine phosphate are exhibited by differential scanning calorimetry DSC. A mixture of the two crystal forms may be demonstrated also by the transition temperatures. May 09, 2019 Aims Chloroquine is a member of the drug class 4-aminoquinoline used for the prevention and treatment of malaria in areas where malaria is known to be sensitive to its effects. Our aim is to synthesize the chloroquine – titanium complex and to study its coordination behavior.

     
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  9. alex_black XenForo Moderator

    Drug spotlight on hydroxychloroquine Lupus Foundation of. Side effects. In some people, HCQ may cause gastrointestinal problems, such as nausea, vomiting, upset stomach, cramps, or diarrhea. These may occur for the first few days a person takes the drug while the body adjusts to the medication. Loss of appetite, tiredness, weakness, or headache are uncommon side effects and typically go away over time.

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