Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. How can plaquenil affect your eyes Plaquenil side effects diarrhea Plaquenil weight based dosing Para que sirve plaquenil While the drug can inhibit certain enzymes, its effect is believed to result, at least in part from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain. Chloroquine is active against the erthyrocytic forms of Plasmodium vivax. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. It is a prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. PubChemThe mechanism of plasmodicidal action of chloroquine is not completely certain. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Chloroquine phosphate mechanism of action Aralen, Chloroquine phosphate chloroquine dosing., Chloroquine Indications, Side Effects, Warnings - Eye test for plaquenil toxicity frequency Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products. Chloroquine - Wikipedia. Chloroquine C18H26ClN3 - PubChem. Aralen chloroquine Malaria Drug Side Effects & Dosage. Chloroquine has a long half-life, which can vary between 74 hours and 50 days, depending on the cumulative dose. The drug can remain in the skin for 6–7 months after the cessation of therapy. Chloroquine dosing. Chloroquine phosphate is dispensed as a 250 mg tablet, which is equivalent to 155 mg chloroquine base. Mechanism of action of Chloroquine It interferes with the metabolism and hemoglobin utilization by the parasites by binding to and inhibiting the DNA and RNA polymerase. It also concentrates within the parasite vesicles and interferes with the acid-base balance of the parasite inhibiting the growth of the parasite. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme.