Please review the following URL and make sure that it is spelled correctly. Hi everybody, I was wondering if Plaquenil's primary mode of action was to suppress the immune system? Plaquenil and grapefruit Plaquenil whorl keratopathy Plaquenil for oa Maker of plaquenil Methotrexate does suppress the immune system, but serious infections with methotrexate are not common. Your rheumatologist will monitor you closely for any side effects associated with methotrexate such as liver test abnormalities, pneumonitis, or infections. Almost all autoimmune diseases require the immune system be suppressed to some degree. Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory. Summary Immune system disorder is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Enbrel, and have Pain. 1 month ago and prior to taking it I rarely ever got sick with colds,flu etc. I am asking this question, because I started this med approx. Plaquenil and immune system Plaquenil and stomach issues." Lupus Community - Support., Taking Plaquenil for Rheumatoid Arthritis How does plaquenil treat lupusBuy hydroxychloroquine sulphateDoes plaquenil cause bile malabsorptionChloroquine retinopathy ppt Plaquenil reduces inflammation in many Rheumatic disorders, the mode of action is pretty complicated though so I shan't bore you with all the details, but basically it prevents your dendritic cells these are messengers for your immune system, if you will from interacting with your T-Cells a special type of white blood cell which through a convoluted and boring process, causes inflammation. Inflammatory Osteoarthritis And Plaquenil. Will you have Immune system disorder with Plaquenil - eHealthMe. Coronavirus and Arthritis What You Need to Know Arthritis Foundation. Re want to know good stuff about plaquenil Sorry to be a party pooper here, but I have been on Plaquenil for 5 months and can't say I feel any difference at all. If anything I am sleeping all day but for just about 1 1/2 hours at a time. Plaquenil itself probably does not have a direct affect on your immune system - it is a DMARD and is not considered to be an immunosuppressant. However, many with active autoimmune diseases feel that they are not succeptible to many of the common viruses that they are exposed to - somewhat of a silver lining. RA is a systemic autoimmune disease in which the immune system attacks the joints and can affect other parts of the body.1 Several drugs to treat RA -- biologics Enbrel, Humira, etc. and DMARDS Plaquenil, methotrexate suppress the immune system.2 Suppressing the immune system helps slow or prevent damage to joints and other body systems.