The importance of early diagnosis and appropriate treatment is paramount. If initial investigations for infectious agents prove negative, other diagnoses must be considered promptly. Which of the following statements concerning chloroquine is correct Plaquenil and arthritis Chloroquine phosphate tablets used for Autoimmune encephalitis AE is an increasingly recognized etiology for neuropsychiatric deficits that are highly responsive to immunotherapy. As a result, rheumatologists are often called upon to help with the diagnosis and treatment of these conditions. The purpose of this review is to provide an update on the pharmacologic treatment of AE. Autoimmune encephalitis is increasingly recognized as the cause of a variety of neuropsychiatric syndromes that can be severe and prolonged. In contrast to the classic paraneoplastic disorders that are poorly responsive to tumor treatment and immunotherapy, autoimmune encephalitis often responds to these treatments, and patients can have full or marked recoveries. Advances in autoimmune encephalitis research in the past 10 years have led to the identification of new syndromes and biomarkers that have transformed the diagnostic approach to these disorders. However, existing criteria for autoimmune encephalitis are too reliant on antibody testing and response to immunotherapy, which might delay the diagnosis. We describe four patients with autoimmune encephalitis—3 auto-antibody positive, 1 auto-antibody negative—treated during the last 18 months. Autoimmune encephalitides are being increasingly recognized as important (and potentially reversible) non-infectious causes of an encephalitic syndrome. Scholarly articles plaquenil autoimmune encep halitis Autoimmune Disorders Peer reviewed High Impact Articles List, Autoimmune encephalitis update Neuro-Oncology Oxford. Malaria treatment drugs chloroquineWhy take chloroquine phosphate 500 mgHydroxychloroquine sulfate tablets usp 200 mg side effects Autoimmune encephalitis causes subacute deficits of memory and cognition, often followed by suppressed level of consciousness or coma. A careful history and examination may show early clues to particular autoimmune causes, such as neuromyotonia, hyperekplexia, psychosis, dystonia, or the presence of particular tumors. The Diagnosis and Treatment of Autoimmune Encephalitis. A clinical approach to diagnosis of autoimmune encephalitis - Europe.. Acute encephalitis in immunocompetent adults - The Lancet. Autoimmune encephalitis AE comprises an expanding group of clinical syndromes that can occur at all ages, but preferentially affect younger adults and children. These disorders associate with antibodies against neuronal cell surface proteins and synaptic receptors involved in synaptic transmission, plasticity, or neuronal excitability. Autoimmune encephalitides are being increasingly recognized as important and potentially reversible non-infectious causes of an encephalitic syndrome. We describe four patients with autoimmune encephalitis—3 auto-antibody positive, 1 auto-antibody negative—treated during the last 18 months. Autoimmune limbic encephalitis results in a combination of acute or subacute onset of short-term memory deficits, behavioral changes, and seizures. It occurs in association with several types of antibodies, including those associated with cancer onconeuronal antibodies to antigens such as Hu, CV2.