While the exact percentage of RA patients who experience sleep problems is hard to nail down, more than 80% of people with RA report fatigue as part of their symptoms. Why Sleep Matters Sleep problems can increase levels of stress hormones and aggravate flares, says Rochelle Rosian, MD, a Cleveland Clinic rheumatologist. Chloroquine msds Malaria treated with chloroquine Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Lupus-Induced Insomnia and a Feeling of Isolation. June 7, 2017 June 7, 2017. by Kristiana Page. In Columns, The Girl Who Cried Wolf - A Column by Kristi Page. Click here to subscribe to the Lupus News Today Newsletter. 0 0 Part of living with lupus is knowing that your body lives outside of the norm. It means accepting that, for the most. Plaquenil doesn't usually cause insomnia. It is most likely something else, such as prednisone if you're taking it or anxiety. Insomnia is a common complaint for people with Lupus, some as a result of the steroids and some from general stress of the disease. Lupus is a difficult diagnosis to handle and can really make it difficult to fall asleep. “When you sleep, you make all those brain chemicals that you need to feel better. And even if you’re not flaring, you may not manage your pain as well if you’re not sleeping. Plaquenil and insomnia Rheumatoid Arthritis and Sleep Arthritis Foundation, Lupus-Induced Insomnia and a Feeling of Isolation Pots dysautonomia plaquenil Treatment includes artificial tears and saliva and, in more severe cases, immune blockers such as prednisone, Plaquenil and even the cancer medication Methotrexate. Jacob Teitelbaum, MD. Print. Comments. The news has been buzzing about Venus Williams dropping out of the US Open because of Sjogren's syndrome. as the combination of insomnia. Why There's More to Sjogren's Syndrome The Dr. Oz Show. Started taking Plaquenil for Lupus and now I can't sleep.. Hydroxychloroquine Plaquenil. Plaquenil has helped me on many levels on many days. I think, for me, anyway, the depression and anxiety I often feel is due to the autoimmune issues/sjogrens. I have not noticed an increase in depression/anxiety since being on the plaquenil but that is just me. Balances out the steroids and im guessing, the Plaquenil, because I had weird issues before with Plaquenil and this time I don't. I know they can be addictive so im careful, and I respect them, I try to skip if I can, but between anxiety from pills helping me to live better, and addicted to nerve pills, I choose all the above and lead a calm life Some medications, such as prednisone and hydroxychloroquine, also have the side effect of causing sleeplessness. It is a good idea to take these drugs earlier in the day to reduce this effect.