Chloroquine resistant and sensitive areas

Discussion in 'Chloroquine Phosphate 500 Mg' started by MMX3000, 29-Feb-2020.

  1. ART-WRITER Guest

    Chloroquine resistant and sensitive areas


    Previously referred to as “Resochin”, Chloroquine was first discovered in 1924 at Bayer laboratories. Its first use was initially ignored as it was found to be toxic to people.

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    For prophylaxis only in areas with chloroquine-sensitive malaria-Prophylaxis should start 1 to 2 weeks before travel to malarious areas; should continue weekly same day each week while in malarious areas and for 4 weeks after leaving such areas. Usual Adult Dose for Malaria. Both species are regarded as very sensitive to chloroquine, although there is a single recent report of chloroquine resistance in P. malariae. P. vivax is still generally very sensitive to chloroquine, although resistance is prevalent and increasing in some areas, notably Oceania, Indonesia and Peru. Because of its record of safety and efficacy, chloroquine remains the primary prophylactic drug of choice for travelers to all malarious areas, including areas with CRPF. In all areas with CRPF, there is malaria caused by one or more other species of Plasmodium P. vivax, P. ovale, P. malariae that remain sensitive to chloroquine.

    These trials showed that chloroquine eliminated malaria and was appropriate to be used as an antimalarial drug. Thus, it was not until World War II that the government of the United States sponsored the clinical trials of chloroquine as an antimalarial drug.

    Chloroquine resistant and sensitive areas

    Malaria - Chapter 4 - 2020 Yellow Book Travelers' Health., Chloroquine C18H26ClN3 - PubChem

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  5. The location of study sites with documented chloroquine resistance and chloroquine sensitive P. vivax is shown in Figure 2a and for chloroquine sensitive sites in Figure 2b below. Estimates for chloroquine sensitivity derived from 112 sites. In 50.9% of the sites estimates P. vivax were categorized as resistant.

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    Multi-drug resistant malaria In areas of Thailand near the borders with Cambodia and Myanmar and in Western Cambodia, P. falciparum infections do not respond to chloroquine or pyrimethamine-sulfadoxine, and sensitivity to quinine is reduced. Treatment failures of over 50% are also being reported. Drug resistance has been implicated in the spread of malaria to new areas and re-emergence of malaria in areas where the disease had been eradi-cated. Drug resistance has also played a significant role in the occurrence and severity of epidemics in some parts of the world. Population movement has introduced resistant parasites to areas. In all areas with CRPF, there is malaria caused by one or more other species of Plasmodium P. vivax, P. ovale, P. malariae that remain sensitive to chloroquine. In addition, chloroquine-sensitive P. falciparum may coexist with chloroquine-resistant parasites within a geographic area.

     
  6. natali84_2008 Moderator

    Background: The American Academy of Ophthalmology recommendations on screening for chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Chloroquine And Hydroxychloroquine Toxicity - StatPearls. Chloroquine Oral Uses, Side Effects, Interactions, Pictures. Recommendations on Screening for Chloroquine and.
     
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  8. ladybird New Member

    Medicines for the Prevention of Malaria While Traveling. Effects of chloroquine? Chloroquine is a relatively well-tolerated. medicine. The most common adverse reactions reported are stomach pain, nausea, vomiting, and headache. These side effects can often be lessened by taking chloroquine with food. Chloroquine may also cause itching in some people. All medicines may have some side effects.

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