Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Hydroxychloroquine plaquenil weight gain Plaquenil skin changes Splitting plaquenil tablets Hydroxychloroquine muscle toxicity I had to stop methotrexate about 7 months ago for my RA, due to bad side effects after using it successfully for 10 years. As an alternative, my rheumy put me on HCQS, also known as plaquenil, along with 5mg of prednisone. But ever since then I've had the runs something terrible, and whatever I do or don't do I can't seem to shake it. Caffeine may reduce the effectiveness of methotrexate in the treatment of arthritis. If you are receiving methotrexate for arthritis, you may want to limit your intake of caffeine-containing foods and products. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Summary Drug interactions are reported among people who take Methotrexate and Plaquenil together. This study is created by eHealthMe based on reports of 23,242 people who take Methotrexate and Plaquenil from Food and Drug Administration FDA, and is updated regularly. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. When to switch from plaquenil to methotrexate Changing from methotrexate and prednisone to methotre. - NRAS, Methotrexate and Alcohol / Food Interactions - Hydroxychloroquine food cravingsEffects of plaquenil on eyesGranulomatous nodules treated with plaquenilPlaquenil toxicity This is a really good article. I am on Plaquenil and Methotrexate. We tried Enbrel for a year, then had to switch to Remicade. Still not working well, we have increased the dosage twice. I am on Prednisone 5mg just as a temporary measure until I go back next week. It is time to move on, but I couldn’t decide between Rituxin, Acterma, or Orencia. Switching Medications Without Waiting too Long RA. Methotrexate and Plaquenil drug interactions - eHealthMe. Treating Rheumatoid Arthritis DMARDs vs. Biologics.. Apr 21, 2017 I had to stop methotrexate about 7 months ago for my RA, due to bad side effects after using it successfully for 10 years. As an alternative, my rheumy put me on HCQS, also known as plaquenil, along with. You just helped educate me. Thanks. I always thought that plaquenil was not a DMARD, but never bothered to look. I do know that plaquenil is generally considered the least invasive drug, generally prescribed as the first line of treatment. Methotrexate is the most commonly prescribed DMARD, but it does come with the chance of side-effects. I took methotrexate injections for five weeks and had horrible effects from it and my rheumy finally said oh well you're not going to be able to take this. I was wondering about switching from plaquenil to arava, but now I'm thinking about maybe asking about just adding the arava.