In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Plaquenil helped migairnes Hydroxychloroquine tonic water Arava and plaquenil FAF demonstrates typical symmetrical high signal haloes in the right eye C and left eye D, which are also visible on the Infrared reflectance image E. SD-OCT shows typical thinning of the inner retinal layers with loss of the parafoveal photoreceptor ellipsoid zone and relative central foveal sparing F. In obvious toxicity, the nasal inner subfield showed more thinning than the temporal inner subfield at 12 months after drug cessation p = 0.018, 95 % CI −1 to −8 μm. Conclusions Once HCQ retinopathy is diagnosed and the medication is discontinued, structural retinal changes commonly occur. SD-OCT scan from a 44-year-old woman with bilateral plaquenil toxicity. There is damage visible in the outer retina in a perifoveal distribution. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Retinal thinning in plaquenil toxicity oct The Risk of Retinal Toxicity with Plaquenil - Sjogren's, Expanded spectral domain-OCT findings in the early. How does hydroxychloroquine cause retinopathy Thinning of the photoreceptor layer, ellipsoid layer, outer nuclear layer, and RPE can be among the earliest signs of hydroxychloroquine toxicity. 4 These changes often occur in the parafoveal area, although they can be more peripheral in Asian patients. Retina Today - Imaging in Hydroxychloroquine Toxicity.. Plaquenil Toxicity - Retina Image Bank. Selective Thinning of the Perifoveal Inner Retina as an.. C, Moderate retinal toxicity, with marked outer retinal thinning on both sides of the fovea arrowheads and a prominent ring scotoma but still no pigmentary changes visible in the fundus. D, Severe retinal toxicity, with bull’s eye maculopathy on the fundus image, disruption of the retinal pigment epithelium on spectral-domain OCT, and severe visual field defects. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Download PDF. Drug-induced ocular side effects are back in the spotlight, thanks to the Academy’s revision of its recommendations on screening for retinal toxicity from chloroquine and its analogue hydroxychloroquine Plaquenil. 1 There are hundreds of drugs with potential retinal toxicity—so many that the National Registry of Drug-Induced Ocular Side Effects doesn’t stratify them by.