Hi everyone, May be I've asked this question before in some other form, but I really would like to know if there is an alternative to Plaquenil. Plaquenil was the only drug for me which gave me instantaneous better saliva flow improved my depression within a week. Plaquenil treatment for rheumatoid arthritis Can hydroxychloroquine cause chronic colutis Here is a short list Prednisone, Imuran, Remicade, Methotrexate. Later sidesteps Prednisone's side effects, which include weight gain, mood swings, diabetes and eye problems, such as cataracts. I hope this was helpful enough. May be I've asked this question before in some other form, but I really would like to know if there is an alternative to Plaquenil. Plaquenil was the only drug for me which gave me instantaneous better saliva flow + improved my depression within a week. I "know" I need some meds, but cannot tolerate Plaquenil. Wondering if anyone has come across something "natural" that mimics it. Thanks & LIGHT*****carole - Hi, Carole. When I started Plaquenil, my GI system was in an uproar. But it usually was anyway. I didn't realize, until I saw Dr. So please anyone, is there something else which can 'kill the bugs' inside me? DES-daughter ('67), Lyme's ('98), GAD ('98), Sjogren's ('02), hypothyroid ('04), endometriosis ('14), osteoarthritis ('16), blepharitis ('18), frozen shoulder ('19). The downside: I got a severe allergic reaction, eye trouble, enormous chills, constipation, weight gain and anorgasmia... Natural alternatives for plaquenil Alternatives to Hydroxychloroquine - Lupus - Inspire, Is there an alternative to Plaquenil? Plaquenil increased fatigueSerious side effects of plaquenilHydroxychloroquine and iron supplementsPancreatitis and plaquenil I'm still searching for that magic "all natural" replacement since I cannot tolerate plaquenil. The stomach, liver & eye complications are too great to bear. and that's at the lowest, lowest dose. Anyway, guess I need to get into some deeper research about exactly what this drug does, and. Alternative" to plaquenil. ProHealth Fibromyalgia, ME.. Natural" alternative to Plaquenil. - HealthBoards. Alternatives to Plaquenil DailyStrength. Doctors give trusted answers on uses, effects, side-effects, and cautions Dr. Namey on plaquenil substitute Plaquenil is also known as hydroxychloroquine, so the parent drug Chloroquine can be substituted. But Chloroquine has significantly higher rate of retinal toxicity, so it isn't used much anymore. Also, Plaquenil appears to effectively reduce flares in patients with lupus not. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. PLAQUENIL should be administered with caution in patients having glucose-6-phosphate dehydrogenase G-6-PD deficiency. Dermatologic Effects. Dermatologic reactions to PLAQUENIL may occur and, therefore, proper care should be exercised when it is administered to any patient receiving a drug with a significant tendency to produce dermatitis.