Why chloroquine is given in loading dose

Discussion in 'Canadian Pharmacy Drugs Online' started by dmsmak, 27-Feb-2020.

  1. Stifler №1 Well-Known Member

    Why chloroquine is given in loading dose


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    For the treatment of RA, hydroxychloroquine is typically taken by mouth once daily at 200-400 mg, although it can be taken at a higher dose. A loading dose of 1,200 mg daily, given for 6 weeks may decrease the time to clinical response. However, experts debate that this higher dosage may increase the risk of toxicity. By the time the government approves any vaccination, the damage by COVID-19 will be done. Why not use something we have available already? Chloroquine. It was cheap and readily available. South Korea included it’s use in their guidelines, and they had an order of magnitude fewer deaths than China! An Effective Treatment for COVID-19 If a diabetic patient being treated with an oral hypoglycemic agent,develops dilutional hyponatremia-which one of the following could be responsible for this effect

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Why chloroquine is given in loading dose

    Aralen Chloroquine Uses, Dosage, Side Effects., Chloroquine for Coronavirus COVID-19 – why aren’t we using.

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    Anyone heard anything about this, or have speculation on if that would be effective at the more tolerable malaria prophylaxis dose or the accelerated loading dose maybe. TI is not great on Chloroquine, and if someone is dying of SARS-CoV-2 you don't care about side effects too much and push it up to the limit, but would be a real concern for. Dosage. Chloroquine can be administered either orally or parenterally for treatment of malaria, but prophylaxis is given in tablet form. An effective blood concentration is reached within 2-3 hours if a loading dose of 600 mg base is used. Inappropriate loading dose reduction resulting in ineffectively low plasma concentration is a significant danger in patients with renal impairment. A single loading dose of antibiotic, equivalent to the usual maintenance dose for patients with normal renal function, should almost always be given to patients with impaired renal function.

     
  8. igor2000xp Well-Known Member

    It is preferable that treatment for malaria should not be initiated until the diagnosis has been established by laboratory investigations. DRUG RESISTANT MALARIA CURRENT STATUS Malaria Guide Causes, Symptoms and Treatment Options Guidelines for Treatment of Malaria in the United States.
     
  9. Smittoh Well-Known Member

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