Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention. Plaquenil tooth decay Hydroxychloroquine side effects forum Hydroxychloroquine side effects bleeding gums Glioblastoma multiforme GBM is one of the most aggressive and fatal brain cancers in existence. Most patients die within two years of diagnosis. However, an increasing number of patients are turning to cannabis oil as a potential treatment for many brain cancers, given the promising anecdotal and scientific evidence. Adding Chloroquine to Conventional Treatment for Glioblastoma Multiforme A Randomized, Double-Blind, Placebo-Controlled Trial. From the National Institute of Neurology and Neurosurgery of Mexico. From the National Institute of Neurology and Neurosurgery of Mexico. Chloroquine and related antimalarial drugs. This class of drugs has been widely used for decades in malaria prevention and therapy. These molecules are effective in blocking P. falciparum life cycle and are relatively well-tolerated. Recently, antimalarial drugs are also considered in cancer chemotherapy 84. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Using chloroquine to treat glioblastoma Chloroquine for Glioblastoma Multiforme Annals of Internal., Chloroquine for Glioblastoma Multiforme Annals of. Does plaquenil reduce pain in osteoarthritisWhat is plaquenil supposed to do to help lupusPlaquenil and shortness of breathHydroxychloroquine vs hydroxychlor Symptoms of Overdose. Some side effects of chloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Chloroquine Side Effects Common, Severe, Long Term.. Drug repurposing for the treatment of glioblastoma.. Frontiers Re-purposing Chloroquine for Glioblastoma.. Three cohorts of 3 patients will receive chloroquine in escalating doses 3 dose levels 200 mg up to 600 mg daily during standard treatment radiotherapy and temozolomide for newly diagnosed GBM. Extra patients can be added to a cohort in case of dose limiting toxicity, resulting in a maximum of 6 patients per dose level. Tional treatment regimens could not be adjusted for because of the small sample size. Conclusions Chloroquine may improve mid-term survival when given in addition to conventional therapy for glioblastoma multi-forme. These results suggest that larger, more definitive studies of chloroquine as adjuvant therapy for glioblastoma are warranted. The anti-malaria drug chloroquine has now been used as a last resort on three brain cancer patients, and in each case, it seems to have overcome the cancer's resistance to traditional treatments. Chloroquine appears to break down the defences that tumours develop in response to cancer-fighting drugs by effectively 'resetting' their vulnerability to treatment.