If you’ve had it for some time, you may even be experiencing the joint deformities that can occur as RA progresses. As you know, any joint deformity can take a significant toll on your joint function as well as your overall quality of life. Plaquenil multiple sclerosis Jc virus and plaquenil Chloroquine with temodor Methotrexate for Your RA. Methotrexate is one of the most effective medications to treat rheumatoid arthritis RA. It's the first drug most doctors prescribe after you’re diagnosed. It will. I am on both methotrexate and plaquenil. I have been on plaquenil for over a year and a half and methotrexate since September. I have had no side effects from either one. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes used to be every 2 weeks. For Rheumatoid Arthritis I was told that I have rheumatoid arthritis a few months back. I have been on Plaquenil now for almost 2 months. It has helped with the pain in my hands and feet. I still have swollen fingers but am waiting for the full affects of the drug. I do not know how common this is but the side effect that I am having is hair loss. Leisurely pursuits like gardening or taking long walks may have lost their appeal as well, largely as a result of the pain and inflammation these joint-based movements can trigger. RA usually attacks the joints of the hands and feet first, which means even simple activities like tying a shoe, brushing your teeth, combing your hair, or getting dressed in the morning can become painful enterprises. Plaquenil and methotrexate for rheumatoid arthritis Effects of methotrexate and hydroxychloroquine combination., Arthritis Which would you pick and why? - Plaquenil or. Malarial chloroquine resistancePlaquenil anxiety depression I am also taking methotrexate, which I have been on for years and prednisone which I also have been on for years. Any help anyone can give me would be appreciated. Thanks. I have Rheumatoid Arthritis and Lupus. Sylviarose Plaquenil and pain" Rheumatoid Arthritis Community.. Methotrexate vs Plaquenil Comparison -. Hydroxychloroquine Plaquenil. Rheumatoid Arthritis Support Group. Rheumatoid arthritis is a chronic, inflammatory, multisystem, autoimmune disorder. It is a disabling and painful condition which can lead to substantial loss of mobility due to pain and joint destruction. Dec 19, 2017 It’s important to remember that those of us living with rheumatoid arthritis who use immunosuppressant medications, such as one of the biologics or methotrexate, should avoid receiving live virus vaccines for risk of developing the infection. This is why the shingles vaccine has been off limits. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Taking methotrexate with hydroxychloroquine has.