Mutations in HLA genes seem to play a crucial role in the pathogenesis of some cases (but not all), likewise silica, aromatic and chlorinated solvents, ketones, trichloroethylene, welding fumes and white spirits exposure seems to contribute to the condition in a small proportion of affected persons. Vitamin D is implicated in the pathophysiology of the disease. Rheumatoid arthritis choosing initial treatment plaquenil vs enbrel Hydroxychloroquine lupus mechanism This is a reivew of how effective Plaquenil hydroxychloroquine sulfate is for Systemic sclerosis scleroderma and for what kind of people. The study is created by eHealthMe from 11 Plaquenil users and is updated continuously. eHealthMe has been monitoring drugs since 2008. Although the medical research community has not come up with any "Proof" that Plaquenil is effective - there are many, many, many people in both the scleroderma & lupus communities who will tell you that Plaquenil was THE drug that helped with symptom relief over the long term with little to no side effects. Immunosuppressants fall under a category of drugs referred to as DMARDs Disease-Modifying Anti-Rheumatic Drugs. ISN. Scleroderma Treatments and Clinical Trials ISN. Effect of disease-modifying anti-rheumatic drugs DMARDs on bone structure and strength in psoriatic arthritis PsA patients. Typical scleroderma is classically defined as symmetrical skin thickening, with about 70% of cases also presenting with Raynaud's phenomenon, nail-fold capillary changes and antinuclear antibodies. An inverse correlation between plasma levels of vitamin D and scleroderma severity has been noted and vitamin D is known to play a crucial role in regulating (usually suppressing) the actions of the immune system. Plaquenil scleraderma Morphea - Diagnosis and treatment - Mayo Clinic, Just Diagnosed with Crest Syndrome & Prescribed Plaquenil. Amaurosis fugax from plaquenil I may be wrong I often am! but I think there are more listed side effects for aspirin than there are for plaquenil; and by a very long shot, it would seem to be safer than steroids, especially for scleroderma patients. Basically, plaquenil's effect is to modulate the immune system, which is something that could be quite beneficial for some of us. Plaquenil pros and cons - Sclero Forums MAIN - Sclero Forums. Disease-Modifying Anti_Rheumatic Drugs DMARDs - Sclero. Plaquenil--used To Treat Crest? - Sclero Forums MAIN.. Localized scleroderma is a rare autoimmune disease with primary affection of the skin, and occasional involvement of the fat tissue, muscle, fascia, and bone. Depending on the clinical subtype, the spectrum of skin lesions ranges from singular plaque lesions to severe generalized or linear subtypes. which may lead to movement restrictions and permanent disability. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as. Nonsterodial anti-inflammatory drugs and hydroxychloroquine Plaquenil help both conditions. Most patients with pure schleroderma do not benefit from corticosteroids. Methotrexate, azathioprine, prednisone or cyclophosphamide help lupus and overlap syndromes, and perhaps scleroderma lung disease.