Chloroquine diphosphate salt solubility

Discussion in 'Canadian Pharcharmy' started by prokonsul83, 25-Feb-2020.

  1. yus Moderator

    Chloroquine diphosphate salt solubility


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine diphosphate salt, CAS 50-63-5, is An antimalarial compound. MF C18H26ClN3•2H3PO4, MW 515.87. Cited in 24 publications Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. Soluble in water Applications Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine diphosphate salt solubility

    Chloroquine - InvivoGen, Chloroquine - Wikipedia

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  4. Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum.

    • Chloroquine phosphate C18H32ClN3O8P2 - PubChem.
    • Chloroquine diphosphate salt, 98% - N4-7-Chloro-4..
    • Chloroquine diphosphate salt - Sigma-Aldrich.

    Endosomal Acidification Inhibitor. Chloroquine is a lysosomotropic agent that prevents endosomal acidification 1. It accumulates inside the acidic parts of the cell, including endosomes and lysosomes. This accumulation leads to inhibition of lysosomal enzymes that require an acidic pH, and prevents fusion of endosomes. Chloroquine is a member of quinolone family and is a weak intercalating agent. Chloroquine is used for treating amebiasis, rheumatoid arthritis, discoid and systemic lupus erythematosus. Application DNA intercalator. Also used to increase transfection efficiency. Chloroquine diphosphate salt has been used • in in vitro antiplasmodial assays Solubility refer to COA. All information about Chloroquine sulfate salt is provided in the MSDS. We deliver compounds with high purity levels and a comprehensive Certificate of Analysis. Connect to your member account to consult the documents. Related products 13C6-Chloroquine diphosphate salt - C2490 2H10-Chloroquine diphosphate salt.

     
  5. madpierrot XenForo Moderator

    Download PDF Many systemic medications may cause retinal toxicity. Chloroquine Side Effects Common, Severe, Long Term. Plaquenil Side Effects Common, Severe, Long Term - Hydroxychloroquine Oral Uses, Side Effects, Interactions, Pictures.
     
  6. Vasek User

    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. CHLOROQUINE PHOSPHATE INJECTION INTRAMED 200 mg/5 mL Coartem artemether-lumefantrine dosing, indications, interactions. Medicines for the Prevention of Malaria While Traveling.
     
  7. ferdinant Well-Known Member

    Sjogren’s Syndrome What You Need to Know Lupus Foundation. Sjogren’s syndrome SS is a chronic autoimmune disorder in which the moisture-producing glands do not function correctly; SS can also affect internal organs. Sjogren’s syndrome is a relatively common disease, although often under-diagnosed.

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