Mixed connective tissue disease (MTCD) is an uncommon systemic inflammatory rheumatic disease. MCTD is a specific subset of the broader category of rheumatic “overlap syndromes”, a term used to describe when a patient has features of more than one classic inflammatory rheumatic disease. Can hydroxychloroquine cause chronic colutis Dose of chloroquine for malaria treatment Chloroquine prevention dose The term "undifferentiated connective tissue disease" UCTD is used to describe a condition in people who have symptoms and lab test results that indicate a systemic autoimmune disorder or connective tissue disease, but which do not meet enough such characteristics to indicate a diagnosis for a well-defined connective tissue disease such as rheumatoid arthritis, systemic lupus erythematosus lupus or scleroderma. Thus, they seem to have another, similar disorder that doctors call. Individuals with mixed connective tissue disease have symptoms that overlap with those of two or more connective tissue diseases. These diseases include systemic lupus erythematosus, polymyositis, scleroderma, and rheumatoid arthritis. Mixed connective tissue disease MCTD or Sharp's syndrome is a human autoimmune disease in which the immune system attacks the body. MCTD combines features of polymyositis, systemic lupus erythematosus, and systemic scleroderma and is thus considered an overlap syndrome. Individuals with an overlap syndrome may, but need not meet, complete diagnostic criteria for one (or more than one) classic rheumatic disease. These classic rheumatic diseases include systemic lupus erythematosus, polymyositis, scleroderma, and rheumatoid arthritis. Plaquenil and mixed connective tissue disease Mixed Connective Tissue Disease MCTD Symptoms & Signs, Mixed Connective Tissue Disease MCTD - NORD National. More energy on plaquenilPlaquenil and liver problemsPlaquenil knee side effectsIs plaquenil processed through the liver Mar 26, 2017 In mixed connective tissue disease, there are elements of lupus, scleroderma and polymyositis, but these often occur at different times in the course of the disease. Making sense of mixed connective tissue disease Healthy.. Plaquenil DailyStrength. Mixed Connective Tissue Disease Symptoms, Causes, and Treatment. May 24, 2018 Mixed connective tissue disease has signs and symptoms of a combination of disorders — primarily lupus, scleroderma and polymyositis. For this reason, mixed connective tissue disease is sometimes referred to as an overlap disease. In mixed connective tissue disease, the symptoms of the separate diseases usually don't appear all at once. UCTD and Plaquenil. Finally, I have seen another rheumy for a second opionion, and have received the diagnosis of Undifferentiated Connective Tissue Disease UCTD that could develop in to Lupus. My blood work is not yet providing solid evidence for a Lupus diagnosis to be made. I am on Plaquenil 400 mg daily 1 caplet in the morning and one in the evening. I have had to see where the problem is and what kind. I was diagnosed with the mixed then last week it was undifferentiated connective tissue disease. Along with constrictive bronchiolitis obliteration. So much is going on.