Trametinib hydroxychloroquine pancreatic cancer

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  1. Anton K. Moderator

    Trametinib hydroxychloroquine pancreatic cancer


    Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties.

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    A recent study shows that the combination of MEK inhibitor trametinib and hydroxychloroquine led to a striking disease response in a patient with pancreatic cancer. O'Hara et al. reported the results from a phase II, single arm study in patients with metastatic colon cancer treated with hydroxychloroquine in combination with standard first-line chemotherapy mFOLFOX6 29. Summary The purpose of this phase I trial is to study the side effects and best dose of hydroxychloroquine when given together with trametinib in treating patients with pancreatic cancer that has spread to nearby tissue, lymph nodes or other places in the body and cannot be removed by surgery. This phase I trial studies the sides effects and best dose of hydroxychloroquine when given together with trametinib in treating patients with pancreatic cancer that has spread to nearby tissue, lymph nodes, or other places in the body and cannot be removed by surgery.

    In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms).

    Trametinib hydroxychloroquine pancreatic cancer

    Mekinist Uses, Dosage, Side Effects & Warnings -, Clinical Trial Finder Pancreatic Cancer Action Network

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  5. The therapy would use a combination of two FDA Food and Drug Administration approved drugs that are currently being used for other types of cancer – namely trametinib and hydroxychloroquine.

    • New therapeutic approach for patients with pancreatic cancer.
    • Trametinib and Hydroxychloroquine in Treating Patients with..
    • Clinical Trials Search - Pancreatic Cancer Action Network.

    Hydroxychloroquine HCQ is an old FDA-approved drug used to treat malaria, and it inhibits autophagy. Based on this discovery and the drug’s availability, HCQ was tested in clinical trials for pancreatic cancer, but it did not have an impact when used alone. TFEB-mediated lysosomal biogenesis and lysosomal drug sequestration confer resistance to MEK inhibition in pancreatic cancer Skip to main content Thank you for visiting Pancreatic Cancer is an online community for sharing information about innovative, science-based treatments for pancreatic cancer. Please note that this information is not intended to be a substitute for professional medical opinion, advice, or diagnosis.

     
  6. ManKeCOne XenForo Moderator

    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Pregnant Travelers - Chapter 7 - 2020 Yellow Book. Lupus and Pregnancy Tips for Living with Lupus While Pregnant
     
  7. daw Moderator

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine - LiverTox - NCBI Bookshelf Plaquenil Uses, Dosage & Side Effects - Hydroxychloroquine Plaquenil
     
  8. aleksakfima New Member

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