I've been on plaquenil for 6 months for suspected Sjogren's syndrome (I don't have antibodies for Sjorgren's or Lupus but I do have Hashimoto's and have all the symptoms for Sjorgren's so the rheumatologist suggested a trial of plaquenil). Basically I've been on the drug since January and saw the rheumatologist on Wednesday to see how things are going. Plaquenil ear ringing Plaquenil for gvhd Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Nov 12, 2009 Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. I hate to be the bearer of bad news, but after quitting methotrexate cold turkey, I went through a period of improved quality of life 2 months, then I took a sharp decline and had the worst joint swelling I've experienced to date. Everyone is different, and since you are taking Plaquenil too, it could be less severe, only time would tell. I do think it's helped with fatigue and muscle pain but it's hard for me to compare to Xmas as when the improvement is so gradual I think it's really hard to notice on a gradual basis. I *think* I'm improving but it's been a gradual process and I said to him that it's quite hard to tell how much of an improvement I'm feeling. Stopping plaquenil cold turkey Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, What is the correct way to discontinue use of plaquenil? Does plaquenil work on osteoarthritis Hindering. I have never seen anyone cured of plaquenil, but I there are so many people cured of lupus through proper nutrition and raising the immune system as being the best approach. Should I stop cold turkey or gradually taper it off? I have seen one case of a boy stopping cold turkey despite the fact that his lupus is still active. Ted's Remedies, Holistic Therapy Lupus Systemic Lupus Erythematosus. Quitting methotrexate cold turkey rheumatoid. Ask the Expert Plaquenil and Sjögren’s. Hi honey, YES.stopping plaquenil for a couple of days can cause symptoms to arise or get worse.needs to be taken exactly as prescribed. Twice a day, every day. Missing one dose wont make a major difference but skipping more then one, or days absolutely can. I was wondering what would happen when you stop taking plaquenil after trying it out for 3- 6 months. You should slowly taper off of methadone instead of quitting cold turkey. Have been on methotrexate 20mg email@example.com for about a year and 1/2. Recently moved and have a new Rheumatoligist who did his own blood test and x-rays, according to him he cannot find the blood factor or damage to any joints to prove that I have RA. I would like to know can I stop taking methotrexate or do I have to ween off of it slowly? Or should I even be thinking of stopping the meds? I.