Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine lupus nephritis Hydroxychloroquine rheumatoid arthritis mechanism The usual hydroxychloroquine dose that is prescribed is 400 mg/day. For this dosage, any woman with an ideal body weight less than 135 pounds would be in the toxic dose range. As one can see, the height that corresponds to an ideal body weight of 135 pounds varies across the formulas. The maximum dose of Plaquenil is 6.5 mg/kg of ideal body weight per day, regardless of whether a person is overweight, underweight, or normal weight. One kilogram kg equals 2.2 pounds. Women with lupus who are OVER their ideal body weight should go by these dosing rules A daily dose of 6.5mg/kg ideal body weight places patients at higher risk, but a daily dose below this level did not preclude the patient from developing toxicity after many years of treatment. A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7 years of a typical dosage 8, 10. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil toxicity ideal body weight Daily Plaquenil Dosage - Crunching Numbers —, Protecting your eyesight when taking Plaquenil Lupus. Plaquenil sjogren disease doesnt work 2019Is plaquenil a diureticTests to get before starting hydroxychloroquine The most recent 2016 guidelines from the American Academy of Ophthalmology AAO recommend the dose of HCQ ≤5 mg/kg real body weight to minimize toxicity 1. According to these new guidelines, the risk of HCQ retinal toxicity is less than 1 % in the first year of therapy and less than 2 % up to 10 years of therapy. New Guidelines on Hydroxychloroquine Dosage - Where Are We.. Hydroxychloroquine Plaquenil Toxicity and.. Plaquenil Toxicity -. The AAO published dosing and screening recommendations for chloroquine and hydroxychloroquine in 2016, revising previous recommendations published in 2011. The current maximum daily HCQ dose recommended by the AAO is 5 mg/kg of real weight. The 2011 guidelines suggested a maximum dose of 6.5 mg/kg of ideal weight. Previous reports indicate that toxicity is rare if dosing is less than 6.5 mg/kg/day. 2 To avoid overdosage, especially in obese patients or those of short stature, dose should be based on height, which allows for an estimation of ideal body weight. The drug clears slowly from the blood, so basing dosage on weight puts obese patients at risk. Aug 30, 2011 A daily dose of 6.5mg/kg ideal body weight places patients at higher risk, but a daily dose below this level did not preclude the patient from developing toxicity after many years of treatment. A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7 years of a typical dosage 8, 10.