Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. It is also used to treat severe psoriasis and and certain forms of rheumatoid arthritis. Plaquenil optometry exam Plaquenil and ibuprofen Mar 17, 2019 Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine has been recommended as a steroid-sparing agent and as a drug that is effective in treating the dermatitis of JDM. 609 Olson and Lindsley 610 reported significant improvement of the rash following 3 months and of muscle weakness after 6 months of treatment in a dose of 2 to 5 mg/kg/day in nine children. Anecdotal experience. Steroids may be reduced gradually in patients who respond to methotrexate. Combined use of methotrexate with gold, penicillamine, hydroxychloroquine, sulfasalazine, or cytotoxic agents, has not been studied and may increase the incidence of adverse effects. Rest and physiotherapy as indicated should be continued. Methotrexate made also be used for purposes not listed in this medication guide. Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you have low blood cell counts, a bone marrow disorder, weak immune system, liver disease (especially if caused by alcoholism), or if you are pregnant or breast-feeding. Methotrexate is usually given after other medications have been tried without successful treatment of symptoms. Some people have died after taking methotrexate every day by accident. Hydroxychloroquine with methotrexate combination steroid Hydroxychloroquine is a safe and effective steroid-sparing., Hydroxychloroquine - an overview ScienceDirect Topics Signs that plaquenil is eye damageSymptoms of plaquenil toxicity Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of “triple therapy” with methotrexate and sulfasalazine. Mechanism The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is unknown but is thought to involve changes in antigen presentation or effects on the innate immune system. Rheumatoid Arthritis Treatment Options Johns Hopkins.. Methotrexate Trexall Side Effects, Dosages, Treatment.. Is hydroxychloroquine a steroid? - Answered by top doctors on.. Predisolone 1-2mg/kg or pulsed intravenous methylprednisolone may be needed to bring the disease under control. Hydroxychloroquine is rarely adequate in this type of disease. Azathioprine, methotrexate or mycophenolate may be useful for their immunosuppressive and steroid-sparing effects. Aug 22, 2006 O'Dell J R, Leff R, Paulsen G, Haire C, Mallek J, Eckhoff P J. et al Treatment of rheumatoid arthritis with methotrexate and hydroxychloroquine, methotrexate and sulfasalazine or a combination of the three medications results of a two year, randomized, double‐blind, placebo‐controlled trial. Arthritis Rheum 2002 46 1164–1170.1170 Hydroxychloroquine. As a treatment for sarcoidosis, the antimalarial drug hydroxychloroquine Plaquenil® is most likely to be effective in patients with dermatologic involve-ment, joint manifestations and hypercalcemia. Due to poten-tial macular toxicity, it is recommended that patients on hydroxychloroquine have an eye examination every 6-12 months.