Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Side effects plaquenil mayo clinic Does plaquenil treat sjogren's The mode of action of chloroquine is still controversial. Proposed mechanisms of action include 1 DNA intercalation, 2 lysosome accumulation and 3 binding to ferriprotoporphyrin IX. Recent data suggest that intercalation into parasite DNA can occur at physiological concentrations of the drug. Purpose Chloroquine is a strong lysosomotropic and DNA-intercalating agent in experimental studies Neurosurgical Focus 142 February, 2003 and an open-label clinical trial the investigators have demonstrated a strong adjuvant effect of chloroquine on the therapy of malignant gliomas. To understand how chloroquine CQ enhances transgene expression in polycation-based, nonviral gene delivery systems, a number of CQ analogues with variations in the aliphatic amino side chain or in the aromatic ring are synthesized and investigated. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine intercalating Synthesis, characterization, and biological activity of., Chloroquine for Treatment of Glioblastoma Multiforme RxWiki Chloroquine phosphate Chloroquine enjoys a renaissance as an antineoplastic therapy Therapeutic Perspective Clin. Invest. 2013 38 745 Table 1. Clinical trials investigating the safety/efficacy of chloroquine or hydroxychloroquine monotherapy or combination therapy. Investigative agents Conditions Trial ID number Phase Location Status Ref. Chloroquine enjoys a renaissance as an antineoplastic therapy. Structure-function correlation of chloroquine and.. Chloroquine - SlideShare. Uses Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live. Chloroquine is a well known anti-malarial agent, apart from which is a lysosomotropic agent, was used along with intercalating agent like methylene blue and anti-viral agents to treat clinically confirmed CHB patients. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme.