Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Leflunomide hydroxychloroquine Plaquenil e nausea Mechanism of action Hydroxychloroquine is weakly basic, which permits its uptake and concentration in a nonionised form within cells. Having entered the lysosomes inside the cell, the acidic environment traps and concentrates the drug in its ionised state. Mechanism of Action. Unknown; may impair complement-dependent antigen-antibody reactions; inhibits locomotion of neutrophils and chemotaxis of eosinophils. Increases pH and interferes with lysosomal degradation of hemoglobin, which in turn interferes with digestive vacuole function. Absorption. Bioavailability Rapid and complete absorption Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. However, following an identical dose of. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Hydroxychloroquine sulphate mechanism of action Hydroxychloroquine, Plaquenil hydroxychloroquine sulfate dosing, indications. Starting plaquenil during pregnancyHydroxychloroquine indications Hydroxychloroquine is classified as an anti-malarial drug. It is similar to chloroquine Aralen and is useful in treating several forms of malaria as well as lupus erythematosus and rheumatoid arthritis. Its mechanism of action is unknown. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Hydroxychloroquine DermNet NZ. Hydroxychloroquine - DrugBank. Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine oral tablet is used for short-term treatment of malaria, but it may be used for long-term treatment of lupus or rheumatoid arthritis. Hydroxychloroquine comes with risks if you. Hydroxychloroquine Sulfate is a synthetic derivative of quinolyl with chemotherapeutic and antibiotic properties, Hydroxychloroquine Sulfate acts against erythrocytic malarial parasites Plasmodium vivax, ovale, and malariae by concentrating in food vacuoles. It inhibits plasmodial heme polymerase and acts through other unknown mechanisms.