I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. Chloroquine retinopathy fa Plaquenil sore mouth Das psychosis induced by hydroxychloroquine Steroids are taken in different ways, and the dosage may vary depending on the condition you have. The table below gives an idea of how often you might need to take steroids. You should always take medication as prescribed by the person treating you. Tablets, liquids and soluble tablets. Usually once a day. Preferably in the morning. You must also make sure to taper EXACTLY as directed by your doctor as not doing so can cause serious issues. If you are having joint pain/inflammation and kidney issues then you should take the prednisone now and continue in confirming your diagnosis of Lupus. As for the plaquenil, this is an 'old school' treatment of Lupus. Dec 15, 2010 hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. Should you take plaquenil with steroids Plaquenil and Prednisone, Danger in taking Plaquenil and Prednisone if its not Lupus. Does plaquenil cause cancerHydroxychloroquine sulfate tabletsHydroxychloroquine monitoring eyesPlaquenil and benadryl Side effects of Plaquenil and prednisone that are similar include nausea, vomiting, or headache. Side effects of Plaquenil that are different from prednisone include stomach pain or cramps, loss of appetite, weight loss, diarrhea, dizziness, spinning sensation, ringing in your ears, mood changes, nervousness, irritability, skin rash, itching, or hair loss. Plaquenil vs. Prednisone Prescription Treatment for.. Methotrexate and plaquenil -. Taking plaquenil and sulfasalazine Arthritis Information. Take Plaquenil for the full prescribed length of time for malaria. Your symptoms may improve before the infection is completely cleared. When treating lupus or arthritis, tell your doctor if your symptoms do not improve after 6 months of treatment. Before taking this medicine. You should not use Plaquenil if you are allergic to hydroxychloroquine. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Aug 29, 2014 One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur.