One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. What does plaquenil do for rheumatoid arthritis Chloroquine alcohol use How do you stop taking plaquenil Plaquenil generic date Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. Dry skin Loss of appetite Abdominal bloating Upset stomach Stomach cramps Retinal damage There is a small chance that retinal damage will occur while taking hydroxychloroquine Plaquenil or chloroquine Aralen. Deposits On The Eye; Erythema Multiforme, A Type Of Allergic Skin Reaction; Glucose-6-Phosphate Dehydrogenase G6PD Deficiency Anemia; Hearing Loss; Heart Failure; Hives Plaquenil’s long half-life in the body can cause irreversible and progressive damage, Dr. Fung said. Similarly, one study reported that 16 women who’d taken hydroxychloroquine or chloroquine, or a combination of the agents, showed no improvement seven years after stopping drug therapy, and progression occurred in six of the cases. 2 It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. What are plaquenil deposits Plaquenil Reviews Everyday Health, Common and Rare Side Effects for Plaquenil Oral Plaquenil drug actionPlaquenil forlimited sclera derma Plaquenil pla´kwĕ-nil trademark for a preparation of hydroxychloroquine, an antiinflammatory and antiprotozoal agent used for treatment of malaria, lupus erythematosus, rheumatoid arthritis, and giardiasis. Plaquenil definition of Plaquenil by Medical dictionary. Rx Side Effects New Plaquenil Guidelines and More - American.. Plaquenil eye problems Mayo Clinic Connect. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. It is now considered for new disease applications in diabetes, heart disease and adjunct cancer therapies 2. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.